Evidence-based resources using the OncoSim model
OncoSim, previously called the Cancer Risk Management Model, is a validated web-based microsimulation tool. It uses the most current Canadian data to help support decision-making for cancer care in Canada and evaluate cancer control strategies. The OncoSim model can create and compare projections of cancer rates, deaths, resource needs, direct health care costs and broader economic impacts, such as lost wages. This is helpful when assessing existing interventions or when developing new interventions for prevention, screening and treatment of common cancers
Recent clinical guidelines, reports, publications and presentations using OncoSim are listed below. In order to access model assumptions and data sources, please request an account. For any inquiries, contact firstname.lastname@example.org.
Guidelines and reports
Canadian Task Force on Preventive Health Care guidelines
- Recommendations on screening for colorectal cancer in primary care (March 2016)
- Recommendations on screening for lung cancer (March 2016)
Canadian Cancer Society annual statistics reports
- Canadian Cancer Statistics, 2016; Special topic: HPV associated cancers
- Canadian Cancer Statistics, 2015; Special topic: Predictions of the future burden of cancer in Canada
Alberta STE* Report, Institute of Health Economics
- Impact of low dose computed tomography for the screening of lung cancer in adults (May 2014)
*STE=Social and System Demographics Analysis, Technology Effects and Effectiveness, Economic Analysis
- Evans WK, Wolfson MC, Flanagan WM, et al. Canadian Cancer Risk Management Model: Evaluation of cancer control. Int J Technol Assess Health Care. 2013 Apr; 29(2):131-9.
- Evans WK, Wolfson M, Flanagan WM, et al. The evaluation of cancer control intervention in lung cancer using the Canadian Cancer Risk Management Model. Lung Cancer Manage. 2012; 1(1):25-33.
- Louie AV, Rodrigues GB, Palma DA, et al. Measuring the population impact of introducing stereotactic ablative radiotherapy for stage I non-small cell lung cancer in Canada. The Oncologist. 2014 Aug; 19(8):880-5.
- Fitzgerald NR, Flanagan WM, Evans WK, et al. Eligibility for low-dose computerized tomography screening among asbestos-exposed individuals. Scand J Work Environ Health. 2015 Apr.
- Flanagan WM, Evans WK, Fitzgerald NR, et al. Performance of the Cancer Risk Management Model lung cancer screening module. Health Reports. 2015 May; 26(5).
- Goffin JR, Flanagan WM, Miller AB et al. The Cost-Effectiveness of Lung Cancer Screening in Canada. JAMA Oncology; 2015;1(6):807-813.
- Evans WK, Flanagan WM, Miller AB, et al. Implementing Low Dose CT Screening for Lung Cancer in Canada: Implications of Alternative At Risk Populations, Screening Frequency and Duration. Curr Oncol. 2016 Jun;23(3):e179-87. Epub 2016 Jun 9.
- Goffin JR, Flanagan WM, Miller AB, et al. Biennial lung cancer screening in Canada with smoking cessation—outcomes and cost-effectiveness. Lung Cancer. 2016 Nov; 101: 98-103.
- Coldman AJ, Phillips N, Brisson J, et al. Using the Cancer Risk Management Model to evaluate colorectal cancer screening options for Canada. Curr Oncol. 2015 Apr; 22(2):e41-50.
Cervical cancer / HPV
- Miller AB, Gribble S, Nadeau C et al. Evaluation of the Natural History of cancer of the cervix, implications for prevention. The Cancer Risk Management Model (CRMM)- Human PapillomaVirus and Cervical components. Journal of Cancer Policy 4 (2015) 1–6.
- Popadiuk C, Gauvreau CL, BhavsarM, et al. Evaluating the health and economic impact of cytology versus primary HPV DNA cervical cancer screening in Canada using the Cancer Risk Management Model (CRMM). Curr Oncol. 2016 Feb; 23(Suppl 1): S56–S63.
- Lacombe J, Gauvreau CL, Memon S, Popadiuk C, Flanagan WM, Nadeau C et al. Exploring the health outcomes of various pan-Canadian cervical cancer screening programs using microsimulation modeling. J. Epidemiol. 2016. 184(1): 78-80.
- Lacombe J, Memon S, Gauvreau G, Popadiuk C, Flanagan WM, Nadeau C, Coldman AJ, Wolfson MC, Miller AB. Exploring the health outcomes of various pan-Canadian cervical screening programs using microsimulation modelling. Oral presentation at the Canadian Society for Epidemiology and Biostatistics National Student Conference. Jun 2016.
- Gauvreau C, Memon S, Lacombe J. Health and economic impacts of organized vs. opportunistic lung cancer screening. Webinar presented for Analytic Capacity Building Initiative. Mar 2016.
- Lung cancer screening and smoking cessation: Scenarios for Pan-Canadian Lung Cancer Screening Network (PLCSN) – May 2014
- Colorectal cancer screening: Scenarios for National Colorectal Cancer Screening Network(NCCSN) – May 2014
- Cervical cancer screening scenarios for pan-Canadian Cervical Screening Initiative – June 2014
- Memon S, Gauvreau C, Lacombe J, Flanagan WM, Goffin JR, Wolfson MW, Miller AB, Evans WK. Comparing the health and economic outcomes of opportunistic lung cancer screening vs. organized lung screening using the Cancer Risk Management Model. Poster presentation for Canadian Centre for Applied Research in Cancer Control. May 2016.
- Annual vs. biennial lung cancer screening – using the Cancer Risk Management Model (CRMM) to fill gaps in evidence – ARCC May 2014
- Comparing the health and economic impacts of two screening strategies for colorectal cancer in Canada using the Cancer Risk Management Model (CRMM) – CAHSPR May 2014
- Infographic: HPV 16 & 18: Just the 2 strains of HPV are the cause of 70% of all cervical cancer cases
To learn how to use the OncoSim platform, download the OncoSim user guide. The guide provides detailed information on the sub-models, as well as examples of applications. You will find out how to understand, analyze, edit, and run various simulations and scenarios within the OncoSim model. It is a practical resource you should keep at your side.
To view other model documentation, such as those on structure and parameters, please request an account.